SUBSTITUTED PYRAZOLO PIPERIDINE CARBOXYLIC ACIDS

BHC201062 FC - 126 - Substituted pyrazolo piperidine carboxylic acids A b s t r a c t The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of...

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Hauptverfasser: SANDNER, Peter, WEBSTER, Robert, Alan, STELLFELD, Timo, BOULTADAKIS-ARAPINIS, Melissa, MATHAR, Ilka, COLLIN-KRÖPELIN, Marie-Pierre, DIETZ, Lisa, SCHMECK, Carsten, MONDRITZKI, Thomas, WUNDER, Frank, HOFMEISTER, Lucas, Hudson, DIESKAU, Andre, CANDISH, Lisa, VAKALOPOULOS, Alexandros, ORTEGA HERNANDEZ, Nuria
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:BHC201062 FC - 126 - Substituted pyrazolo piperidine carboxylic acids A b s t r a c t The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU). La invención se refiere a ácidos pirazolo piperidin carboxílicos sustituidos, sus sales y a procesos para su preparación, y también a su uso para la preparación de medicamentos para el tratamiento y/o la profilaxis de enfermedades, en particular enfermedades cardiovasculares y cardíacas, preferiblemente insuficiencia cardíaca con fracción de eyección reducida y conservada (HFrEF, HFmrEF y HFpEF), hipertensión (HTN), enfermedades de arterias periféricas (PAD, PAOD), enfermedades cardiorrenales y renales, preferiblemente enfermedad renal crónica y diabética (CKD y DKD), enfermedades cardiopulmonares y pulmonares, preferiblemente hipertensión pulmonar (PH), y otras enfermedades, preferiblemente enfermedades neurodegenerativas y diferentes formas de demencias, enfermedades fibróticas, esclerosis sistémica (SSc), enfermedad de células falciformes (SCD), trastornos de cicatrización de heridas como la úlcera del pie diabético (DFU).