DRUG ANTIBODY CONJUGATES

Drug conjugates having formula [D-(X)b-(AA)w-(T)g-(L)-]n-Ab wherein: D is a drug moiety having the following formula (I) or a pharmaceutically acceptable salt, ester, solvate, tautomer or stereoisomer thereof, (I) wherein D is covalently attached via a hydroxy or amine group to (X)b if any, or (AA)w...

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Bibliographische Detailangaben
Hauptverfasser:	CUEVAS MARCHANTE, María Del Carmen, FRANCESCH SOLLOSO, Andrés M, LATORRE LOZANO, Alfonso, MARTÍNEZ BARRASA, Valentín
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Drug conjugates having formula [D-(X)b-(AA)w-(T)g-(L)-]n-Ab wherein: D is a drug moiety having the following formula (I) or a pharmaceutically acceptable salt, ester, solvate, tautomer or stereoisomer thereof, (I) wherein D is covalently attached via a hydroxy or amine group to (X)b if any, or (AA)w if any, or to (T)g if any, or (L); that are useful in the treatment of cancer. Los conjugados de la fórmula [D-(X)b-(AA)w-(T)g-(L)-]n-Ab en donde: D es un resto de la droga con la siguiente fórmula (I) o una sal, ester, solvato, tautómero o esteroisómero suyo farmacéuticamente aceptable, en donde D sen encuentra unido covalentemente mediante un grupo hidroxi o amino con (X)b si lo hubiera, o (AA)w si lo hubiera, o a T)g si lo hubiera, o a (L); que son útiles en el tratamiento del cáncer.