ISOFORM-SELECTIVE ANTI-TGF-BETA ANTIBODIES AND METHODS OF USE

La invención proporciona anticuerpos anti-TGFß con selectividad de isoforma y métodos de uso de estos. En particular, se proporcionan anticuerpos monoclonales anti-TGFß2, anti-TGFß3 y anti-TGFß2/3 con selectividad de isoforma, por ejemplo, para el tratamiento de la fibrosis y otros trastornos relaci...

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Bibliographische Detailangaben
Hauptverfasser:	WU, Jia, SESHASAYEE, Dhaya, ARRON, Joseph R, SUN, Tianhe, LIN, WeiYu, DEPIANTO, Daryle, YIN, Jian Ping, LIANG, Wei-Ching, RAMALINGAM, Thirumalai Rajan, WU, Yan, TYAGI, Tulika, HALPERN, Wendy Green, LUPARDUS, Patrick J
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	La invención proporciona anticuerpos anti-TGFß con selectividad de isoforma y métodos de uso de estos. En particular, se proporcionan anticuerpos monoclonales anti-TGFß2, anti-TGFß3 y anti-TGFß2/3 con selectividad de isoforma, por ejemplo, para el tratamiento de la fibrosis y otros trastornos relacionados con TGFß. The invention provides isoform-selective anti-TGFβ antibodies and methods of using the same. In particular, isoform-selective anti-TGFβ2, anti-TGFβ3, and anti-TGFβ2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGFβ-related disorders.