TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA

Compounds that inhibit HIF-2a, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases disorders, and conditions, including cancer- and...

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Hauptverfasser:	DREW, Samuel Lawrie, EPPLIN, Matthew, MOON, Hyunyoung, LINDSEY, Erick Allen, LAWSON, Kenneth Victor, POWERS, Jay Patrick, BEATTY, Joel Worley, JACOB, Steven Donald, GAL, Balint, MAILYAN, Artur Karenovich, FOURNIER, Jeremy Thomas Andre, MANDAL, Debashis, LELETI, Manmohan Reddy, WANG, Zhang, KALISIAK, Jaroslaw, MATA, Guillaume, ROSEN, Brandon Reid, JEFFREY, Jenna Leigh, HAELSIG, Karl T, HARDMAN, Clayton, TRAN, Anh Thu, YU, Kai, SU, Yongli, GUNEY, Tezcan, YAN, Xuelei
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Compounds that inhibit HIF-2a, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2a. En el presente documento se describen compuestos que inhiben HIF-2α, asi como composiciones que contienen los compuestos y metodos para sintetizar los compuestos. Tambien se describe el uso de dichos compuestos y composiciones para el tratamiento de una variedad de enfermedades, trastornos y afecciones, incluidos los trastornos relacionados con el cancer y el sistema inmunitario que estan mediados, al menos en parte, por HIF-2α.