SUBSTITUTED STRAIGHT CHAIN SPIRO DERIVATIVES
Provided herein are pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, my...
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| creator | LI, Kangying DARVILLE, Nicolas Freddy J THURING, Johannes Wilhelmus John F DAI, Xuedong XU, Yanping FANG, Lichao FU, Liqiang NG, Alicia Tee Fuay URBANIETZ, Gregor Thomas DENG, Xiangjun MATON, William, Marc ZHAO, Qiwu LIU, Yingtao PANDE, Vineet CAI, Wei QUEROLLE, Olivier Alexis Georges CLEATOR, Edward LIU, Lianzhu LI, Ming |
| description | Provided herein are pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.
La presente invención se refiere a agentes farmacéuticos útiles para la terapia y/o profilaxis en un mamífero, a una composición farmacéutica que comprende tales compuestos y a su uso como inhibidores de la interacción proteína/proteína de la menina/MLL, útiles para tratar enfermedades tales como el cáncer, que incluye, sin carácter limitante, leucemia, síndrome mielodisplásico (SMD) y neoplasias mieloproliferativas (NMP); y diabetes. |
| format | Patent |
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La presente invención se refiere a agentes farmacéuticos útiles para la terapia y/o profilaxis en un mamífero, a una composición farmacéutica que comprende tales compuestos y a su uso como inhibidores de la interacción proteína/proteína de la menina/MLL, útiles para tratar enfermedades tales como el cáncer, que incluye, sin carácter limitante, leucemia, síndrome mielodisplásico (SMD) y neoplasias mieloproliferativas (NMP); y diabetes.</description><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221026&DB=EPODOC&CC=CR&NR=20220346A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221026&DB=EPODOC&CC=CR&NR=20220346A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LI, Kangying</creatorcontrib><creatorcontrib>DARVILLE, Nicolas Freddy J</creatorcontrib><creatorcontrib>THURING, Johannes Wilhelmus John F</creatorcontrib><creatorcontrib>DAI, Xuedong</creatorcontrib><creatorcontrib>XU, Yanping</creatorcontrib><creatorcontrib>FANG, Lichao</creatorcontrib><creatorcontrib>FU, Liqiang</creatorcontrib><creatorcontrib>NG, Alicia Tee Fuay</creatorcontrib><creatorcontrib>URBANIETZ, Gregor Thomas</creatorcontrib><creatorcontrib>DENG, Xiangjun</creatorcontrib><creatorcontrib>MATON, William, Marc</creatorcontrib><creatorcontrib>ZHAO, Qiwu</creatorcontrib><creatorcontrib>LIU, Yingtao</creatorcontrib><creatorcontrib>PANDE, Vineet</creatorcontrib><creatorcontrib>CAI, Wei</creatorcontrib><creatorcontrib>QUEROLLE, Olivier Alexis Georges</creatorcontrib><creatorcontrib>CLEATOR, Edward</creatorcontrib><creatorcontrib>LIU, Lianzhu</creatorcontrib><creatorcontrib>LI, Ming</creatorcontrib><title>SUBSTITUTED STRAIGHT CHAIN SPIRO DERIVATIVES</title><description>Provided herein are pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.
La presente invención se refiere a agentes farmacéuticos útiles para la terapia y/o profilaxis en un mamífero, a una composición farmacéutica que comprende tales compuestos y a su uso como inhibidores de la interacción proteína/proteína de la menina/MLL, útiles para tratar enfermedades tales como el cáncer, que incluye, sin carácter limitante, leucemia, síndrome mielodisplásico (SMD) y neoplasias mieloproliferativas (NMP); y diabetes.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAJDnUKDvEMCQ1xdVEIDgly9HT3CFFw9nD09FMIDvAM8ldwcQ3yDHMM8QxzDeZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfHOQUYGRkYGxiZmjsZEKAEAe_wlGw</recordid><startdate>20221026</startdate><enddate>20221026</enddate><creator>LI, Kangying</creator><creator>DARVILLE, Nicolas Freddy J</creator><creator>THURING, Johannes Wilhelmus John F</creator><creator>DAI, Xuedong</creator><creator>XU, Yanping</creator><creator>FANG, Lichao</creator><creator>FU, Liqiang</creator><creator>NG, Alicia Tee Fuay</creator><creator>URBANIETZ, Gregor Thomas</creator><creator>DENG, Xiangjun</creator><creator>MATON, William, Marc</creator><creator>ZHAO, Qiwu</creator><creator>LIU, Yingtao</creator><creator>PANDE, Vineet</creator><creator>CAI, Wei</creator><creator>QUEROLLE, Olivier Alexis Georges</creator><creator>CLEATOR, Edward</creator><creator>LIU, Lianzhu</creator><creator>LI, Ming</creator><scope>EVB</scope></search><sort><creationdate>20221026</creationdate><title>SUBSTITUTED STRAIGHT CHAIN SPIRO DERIVATIVES</title><author>LI, Kangying ; 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and diabetes.
La presente invención se refiere a agentes farmacéuticos útiles para la terapia y/o profilaxis en un mamífero, a una composición farmacéutica que comprende tales compuestos y a su uso como inhibidores de la interacción proteína/proteína de la menina/MLL, útiles para tratar enfermedades tales como el cáncer, que incluye, sin carácter limitante, leucemia, síndrome mielodisplásico (SMD) y neoplasias mieloproliferativas (NMP); y diabetes.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SUBSTITUTED STRAIGHT CHAIN SPIRO DERIVATIVES |
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