N-SUBSTITUTED-DIOXOCYCLOBUTENYLAMINO-3-HYDROXY-PICOLINAMIDES USEFUL AS CCR6 INHIBITORS
The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of...
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| creator | SCHMITT, Daniel Copley LOMBARDO, Vincent Michael UNWALLA, Rayomand Jal MOUSSEAU, James John SCHNUTE, Mark, Edward GERSTENBERGER, Brian Stephen KUNG, Daniel Wei-Shung THORARENSEN, Atli FLICK, Andrew Christopher ROBINSON, Jr., Ralph Pelton NUHANT, Philippe Marcel WU, Huixian TRUJILLO, John Isidro |
| description | The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.
La presente invencion se refiere a compuestos de dioxociclobutenilamino-3- hidroxi-picolinamida N-sustituida de las Formulas (IA y IB) Formula (IA) Formula (IB) o una sal o hidrato de aquellos aceptables desde el punto de vista farmaceutico, que inhiben el receptor de quimiocinas CC 6 (CCR6), a composiciones farmaceuticas que contienen estos compuestos, y al uso de estos compuestos para tratar o prevenir enfermedades, afecciones o trastornos que mejoran mediante inhibicion de CCR6. |
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La presente invencion se refiere a compuestos de dioxociclobutenilamino-3- hidroxi-picolinamida N-sustituida de las Formulas (IA y IB) Formula (IA) Formula (IB) o una sal o hidrato de aquellos aceptables desde el punto de vista farmaceutico, que inhiben el receptor de quimiocinas CC 6 (CCR6), a composiciones farmaceuticas que contienen estos compuestos, y al uso de estos compuestos para tratar o prevenir enfermedades, afecciones o trastornos que mejoran mediante inhibicion de CCR6.</description><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210520&DB=EPODOC&CC=CR&NR=20210146A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210520&DB=EPODOC&CC=CR&NR=20210146A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SCHMITT, Daniel Copley</creatorcontrib><creatorcontrib>LOMBARDO, Vincent Michael</creatorcontrib><creatorcontrib>UNWALLA, Rayomand Jal</creatorcontrib><creatorcontrib>MOUSSEAU, James John</creatorcontrib><creatorcontrib>SCHNUTE, Mark, Edward</creatorcontrib><creatorcontrib>GERSTENBERGER, Brian Stephen</creatorcontrib><creatorcontrib>KUNG, Daniel Wei-Shung</creatorcontrib><creatorcontrib>THORARENSEN, Atli</creatorcontrib><creatorcontrib>FLICK, Andrew Christopher</creatorcontrib><creatorcontrib>ROBINSON, Jr., Ralph Pelton</creatorcontrib><creatorcontrib>NUHANT, Philippe Marcel</creatorcontrib><creatorcontrib>WU, Huixian</creatorcontrib><creatorcontrib>TRUJILLO, John Isidro</creatorcontrib><title>N-SUBSTITUTED-DIOXOCYCLOBUTENYLAMINO-3-HYDROXY-PICOLINAMIDES USEFUL AS CCR6 INHIBITORS</title><description>The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.
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La presente invencion se refiere a compuestos de dioxociclobutenilamino-3- hidroxi-picolinamida N-sustituida de las Formulas (IA y IB) Formula (IA) Formula (IB) o una sal o hidrato de aquellos aceptables desde el punto de vista farmaceutico, que inhiben el receptor de quimiocinas CC 6 (CCR6), a composiciones farmaceuticas que contienen estos compuestos, y al uso de estos compuestos para tratar o prevenir enfermedades, afecciones o trastornos que mejoran mediante inhibicion de CCR6.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | N-SUBSTITUTED-DIOXOCYCLOBUTENYLAMINO-3-HYDROXY-PICOLINAMIDES USEFUL AS CCR6 INHIBITORS |
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