N-SUBSTITUTED-DIOXOCYCLOBUTENYLAMINO-3-HYDROXY-PICOLINAMIDES USEFUL AS CCR6 INHIBITORS

N-SUBSTITUTED-DIOXOCYCLOBUTENYLAMINO-3-HYDROXY-PICOLINAMIDES USEFUL AS CCR6 INHIBITORS

The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SCHMITT, Daniel Copley, LOMBARDO, Vincent Michael, UNWALLA, Rayomand Jal, MOUSSEAU, James John, SCHNUTE, Mark, Edward, GERSTENBERGER, Brian Stephen, KUNG, Daniel Wei-Shung, THORARENSEN, Atli, FLICK, Andrew Christopher, ROBINSON, Jr., Ralph Pelton, NUHANT, Philippe Marcel, WU, Huixian, TRUJILLO, John Isidro
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6. La presente invencion se refiere a compuestos de dioxociclobutenilamino-3- hidroxi-picolinamida N-sustituida de las Formulas (IA y IB) Formula (IA) Formula (IB) o una sal o hidrato de aquellos aceptables desde el punto de vista farmaceutico, que inhiben el receptor de quimiocinas CC 6 (CCR6), a composiciones farmaceuticas que contienen estos compuestos, y al uso de estos compuestos para tratar o prevenir enfermedades, afecciones o trastornos que mejoran mediante inhibicion de CCR6.