USE OF KLK5 ANTAGONISTS FOR TREATMENT OF A DISEASE

Se proporcionan en la presente métodos para tratar a un sujeto, métodos para predecir la respuesta de un sujeto y seleccionar a un sujeto que padece una enfermedad relacionada con KLK5, tal como asma o síndrome de Netherton. En particular, se proporcionan en la presente usos de antagonistas de KLK5 para el tratamiento o diagnóstico de asma o síndrome de Netherton, tal como un anticuerpo o un polipéptido de fusión a Fc, así como también formulaciones farmacéuticas que los comprenden.Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with KLK5, such as asthma or Netherton Syndrome. In particular, provided herein are uses of KLK5 antagonists for the treatment or diagnosis of asthma or Netherton Syndrome, such as an antibody or an Fc fusion polypeptide as well as pharmaceutical formulations comprising the same. Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with KLK5, such as asthma or Netherton Syndrome. In particular, provided herein are uses of KLK5 antagonists for the treatment or diagnosis of asthma or Netherton Sydrome, such as an antibody or an Fc fusion polypeptide as well as pharmaceutical formulations comprising the same.