FORMULACIONES DE ANTICUERPOS

Esta invencion se refiere a formulaciones de anticuerpo estables a la temperatura y la cizalladura que son mas estables comparadas con una formulacion estandar (tal como citrato 30 mM, NaCl 100 mM, pH 6,5). This invention relates to a shear and temperature stable antibody formulations that are more...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	AMOL SHARAD KETKAR, ULLA TOVE LASHMAR, CHARLENE E BRISBANE
Format:	Patent
Sprache:	spa
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	Esta invencion se refiere a formulaciones de anticuerpo estables a la temperatura y la cizalladura que son mas estables comparadas con una formulacion estandar (tal como citrato 30 mM, NaCl 100 mM, pH 6,5). This invention relates to a shear and temperature stable antibody formulations that are more stable than compared to a standard formulation (such as 30 mM citrate, 100mM NaCl, pH 6.5). The present invention's shear and temperature stable antibody formulations show reduced precipitation when subjected to stress conditions but the standard formulation had aggregated. This result was unpredictable because thermodynamically the two formulations are similar as seen by their DSC (differential scanning calorimeter) profiles.