INHIBIDORES DE 11-BETA HIDROXIESTEROIDE DESHIDROGENASA TIPO I DE TRIAZOLOPIRIDINA

1.- Un compuesto de fórmula Isus enantiómeros, diastereoisómeros o sales, en la que:O es L, Laa o Lee;X es C e Y es N; oX es N e Y es C;G es R4, R4aa o R4ee;L es -alquenil-(W1)n, -cicloalquil-(W1)n o -alquil-(W2)n; Laa es -alquenil-(W1)n o -alquil-(W2aa)n;Lee es -alquenil-(W1ee)n, -cicloalquil-(W1)n o -alquil-(W2ee)n; n es 1 a 3;W1, cada vez que aparece, es independientemente halógeno, -OH, -CN, -CO2R6, -CONR8R8a, -OCONR8R8a, -SO2NR8R8a, -SOR6, -SO2R6, NR9SO2R9a, -NR9CO2R9a, -NR9COR9a, aquilo, cicloalquilo, haloalquilo, alcoxi, ariloxi, haloalcoxi, alquiltio, ariltio, arilsulfonilo, alquilamino, amino, aminoalquilo, arilamino o heteroarilamino;W1ee es independientemente halógeno, -OH, -CN, -CO2R6, -CONR8R8a, -OCONR8R8a, -SO2NR8R8a, -SOR6, -SO2R6, -NR9SO2R9a, NR9CO2R9a, -NR9COR9a, cicloalquilo, alquilo, haloalquilo, alcoxi, ariloxi, haloalcoxi, alquiltio, ariltio, arilsulfonilo, alquilamino, amino, aminoalquilo, arilamino o heteroarilamino;W2 es independientemente halógeno, -OH, -CO2H, -CN, -CO2R6, -CONR8R8a, -OCOR6, OCONR8R8a, -SO2NR8R8a, -SO-alquilo, -SO2-alquilo, -NR9SO2R9a, -NR9CO2R9a, -NR9COR9a, cicloalquilo, alquilo, haloalquilo, alcoxi, alquenilo, haloalcoxi, alquiltio, alquilamino, amino o aminoalquilo;W2aa es independientemente halógeno, -OH, -CN, -CO2H, -CO2R6, -CONR8R8a, -OCOR6, -OCONR8R8a, -SO2NR8R8a, -SO-alquilo, -SO2-alquilo, -NR9SO2R9a, -NR9CO2R9a, -NR9COR9a, cicloalquilo, alquilo, haloalquilo, alquenilo, haloalcoxi, alquiltio, amino, aminoalquilo; ... Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds of formula I: or stereoisomers or pharmaceutically acceptable salts thereof, wherein G, Q, X, Y, R3, R3a, and R3b are defined herein.