Procedimiento para la fabricación de (6r,10s)-10-{4-[5-cloro-2-(4-cloro-1h-1,2,3-triazol-1-il)fenil]-6-oxo-1(6h)-pirimidinil}- 1-(difluorometil)-6-metil-1 4,7,8,9,10-hexahidro-11,15-(meteno)pirazolo[4,3-b][1,7]diazaciclotetradecin-5(6h)-ona

Procedimiento para la fabricación de (6r,10s)-10-{4-[5-cloro-2-(4-cloro-1h-1,2,3-triazol-1-il)fenil]-6-oxo-1(6h)-pirimidinil}- 1-(difluorometil)-6-metil-1 4,7,8,9,10-hexahidro-11,15-(meteno)pirazolo[4,3-b][1,7]diazaciclotetradecin-5(6h)-ona

La presente solicitud se refiere en general a varios procesos para la preparación de (6R, 10S)-10-{4-[5-cloro-2-(4-cloro-1H-1,2,3-triazol-1-il)fenil]-6-oxo-1(6H)-pirimidinil}-1-(difluorometil) -6-metil-1,4,7,8,9,10-hexahidro-11,15-(meteno)pirazolo[4,3 -b][1,7]diazaciclotetradecina-5(6H)-ona: Compues...

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Hauptverfasser: SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander
Format: Patent
Sprache:spa
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APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:La presente solicitud se refiere en general a varios procesos para la preparación de (6R, 10S)-10-{4-[5-cloro-2-(4-cloro-1H-1,2,3-triazol-1-il)fenil]-6-oxo-1(6H)-pirimidinil}-1-(difluorometil) -6-metil-1,4,7,8,9,10-hexahidro-11,15-(meteno)pirazolo[4,3 -b][1,7]diazaciclotetradecina-5(6H)-ona: Compuesto (I). The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one: Compound (I).