Biaryl derivatives

Compounds represented by the general formula (I) which exhibit mGluR1-inhibitory activity and are effective in the treatment and/or prevention of convulsion, acute pain, encephalopathy due to cerebral infarction or transient cerebral ischemic attack, pathergasia such as schizophrenia, anxiety, drug dependence, or Parkinson's disease: (I) wherein R 1 is straight-chain or branched alkoxy, cycloalkoxy, straight-chain or branched lower alkyl, or the like; R2 is halogeno, lower alkyl, or the like; Q1 is carbon or nitrogen; Q2 is carbon which may be substituted with oxo; the symbol of formula (III) (II) represents a single or double bond; A is a group selected from group a of substituents; and R5 is hydrogen, lower alkyl (which may be substituted with alkoxy), cyano, alkoxy, or trialkylsilyl.