Interferon alpha mutant and its polyethylene glycol derivative

The invention discloses an interferon alpha mutant and carbowax derivant and making method and application, wherein the carbowax is covalent on the free Cys residue of interferon alpha mutant, which is characterized by the following: modifying present four interfereons with MIFN, IFN-Con 1, IFN alph...

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1. Verfasser:	JINYI,NIU LIU
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention discloses an interferon alpha mutant and carbowax derivant and making method and application, wherein the carbowax is covalent on the free Cys residue of interferon alpha mutant, which is characterized by the following: modifying present four interfereons with MIFN, IFN-Con 1, IFN alpha-2a and IFN alpha-2b; replacing amino acid at 86 or 85 position into Cys to express effectively; establishing purifying method of new molecule; testing biological activity through WISH/VSV method; decorating PEG; purifying decorated product; detecting external anti-virus activity of interferon alpha mutant.