Butyrylcholinesterase selective inhibitors

The invention provides butyrylcholinesterase inhibitors of Formula I which contain an heterocyclic moiety and a 4 piperidine moiety with a linker in between. The compounds show a very high activity and selectivity towards BuChE, making them useful for the treatment and or prophylaxis or cognitive di...

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Bibliographische Detailangaben
1. Verfasser:	MARTINEZ GIL ANA,RUBIO ARRIETA LAURA,MUNOZ RUIZ PILAR,DORRONSORO DIAZ ISABEL,GARCIA PALOMERO ESTHER,DEL MONTE MILLAN MARIA,MEDINA PADILLA MIGUEL
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides butyrylcholinesterase inhibitors of Formula I which contain an heterocyclic moiety and a 4 piperidine moiety with a linker in between. The compounds show a very high activity and selectivity towards BuChE, making them useful for the treatment and or prophylaxis or cognitive disorders and/or neurodegenerative disorders.