Amlodipine gentisate and a method of its preparation

The present invention relates to an acid salt of amlodipine gentisate and a method of its preparation. More particularly, the present invention relates to a crystalline acid salt of amlodipine gentisate of the following formula 1 prepared by reacting amlodipine and gentisic acid, which is useful for...

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1. Verfasser: KIM JAE-SUN,CHOI JIN YOUNG,RYU JE HO,LEE NAM KYU,JANG JEONG-SOO,JANG WOO JAE,UM KEY AN,KUM DO SEUNG
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to an acid salt of amlodipine gentisate and a method of its preparation. More particularly, the present invention relates to a crystalline acid salt of amlodipine gentisate of the following formula 1 prepared by reacting amlodipine and gentisic acid, which is useful for the treatment of cardiovascular diseases and has the advantages of low toxicity, excellent stability, improved pharmaceutical efficacies and long-lasting concentration in blood.