Thiadiazolidinones as gsk-3 inhibitors

Thiadiazolidinones as gsk-3 inhibitors

Provided arc thiadiazolidinc compounds of formula I wherein R1 is an organic group having at least 8 atoms selected from C or O, which is not linked directly to the N through a -C(O)- and comprising at least an aromatic ring, and their pharmaceutical compositions. These compounds are selective GSK-3...

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Bibliographische Detailangaben
1. Verfasser: MARTINEZ GIL,DORRONSORO DIAZ ISABEL,ALONSO CASCONMERCEDES,PANIZODEL PLIEGO GEMA,FUERTES HUERTA ANA,PEREZ PUERTO MARIA JOSE,MEDINA PADILLA MIGUEL
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Provided arc thiadiazolidinc compounds of formula I wherein R1 is an organic group having at least 8 atoms selected from C or O, which is not linked directly to the N through a -C(O)- and comprising at least an aromatic ring, and their pharmaceutical compositions. These compounds are selective GSK-3 inhibitors and have improved bioavailability. They are useful for the treatment of GSK-3 mediated diseases, among others Alzheimer's disease, type II diabetes, depression and brain injury.