6-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists

6-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists

The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT 2C receptor agonists for the treatment of 5-HT 2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R 6 is -S-L-R 15 and other subst...

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Hauptverfasser: ALLEN JOHN GORDON,BRINER KARIN,COHEN MICHAEL PHILIP,GALKA CHRISTOPHER STANLEY,HELLMAN SARAH LYNNE,MARTINEZ-GRAU MARIA ANGELES,REINHARD MATTHEW ROBERT,RODRIGUEZ MICHAEL JOHN,ROTHHAAR ROGER RYAN,TIDWELL, REW CAERWYN,ZHANG DEYI,BOYD STEVEN ARMEN,CONWAY RICHARD GERARD,DEO ARUNDHATI S.,LEE WAI-MAN,SIEDEM CHRISTOPHER STEPHEN,SINGH AJAY
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT 2C receptor agonists for the treatment of 5-HT 2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R 6 is -S-L-R 15 and other substituents are as defined in the specification.