Heterocyclic aspartyl protease inhibitors

Heterocyclic aspartyl protease inhibitors

Compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascul...

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Hauptverfasser: LE THUY X. H.,SAIONZ KURT W.,BABU SURESH D.,HUNTER RACHAEL C, ZHU ZHAONING,MCKITTRICK BRIAN,SUN ZHONG-YUE,YE YUANZAN C.,VOIGT JOHANNES H.,STRICKLAND COREY,SMITH ELIZABETH M.,STAMFORD ANDREW,GREENLEE WILLIAM J.,MAZZOLA ROBERT,CALDWELL JOHN,CUMMING JARED N.,WANG L
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic antagonist.