Nucleotide analog compositions

The present invention relates to a method for preparing adefovir dipivoxil comprising contacting 9-Ä2-(phosphonomethoxy)ethylÜadenine with chloromethyl pivalate in 1-methyl-2-pyrrolidinone and a trialkylamine and recovering adefovir dipivoxil.

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Bibliographische Detailangaben
1. Verfasser:	ARIMILLI MURTY N.,LEE THOMAS T. K.,MANES LAWRENCEV.,MUNGER JOHN D. JR.,PRISBE ERNEST J.,SCHULTZE LISA M.,KELLY DAPHNE E
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a method for preparing adefovir dipivoxil comprising contacting 9-Ä2-(phosphonomethoxy)ethylÜadenine with chloromethyl pivalate in 1-methyl-2-pyrrolidinone and a trialkylamine and recovering adefovir dipivoxil.