Capsaicin receptor agonists

Capsaicin receptor agonists are provided. Such compounds are ligands that may be used to modulate VR1 activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to capsaicin receptor activation in humans, domesticated companion animals and livestock animals....

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1. Verfasser: BAKTHAVATCHALAM RAJAGOPAL,BLUM CHARLES A.,BRIELMANN HARRY,CALDWELL TIMOTHY M.,CORTRIGHT DANIEL N.,HODGETTS KEVIN J.,PETERSON JOHN M.,ZHENG XIAOZHANG
Format: Patent
Sprache:eng
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Zusammenfassung:Capsaicin receptor agonists are provided. Such compounds are ligands that may be used to modulate VR1 activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to capsaicin receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.