A sustained release anticancer agent containing clorfarabine and cytotoxic drug

Disclosed is an anticancer slow release injection containing clofarabine and cytotoxic drugs, which comprises slow release micro-balloons and dissolvent, wherein the slow release microballoons comprise anti-cancer active constituents and slow release auxiliary materials, the dissolvent being specifi...

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1. Verfasser: ZHONGHOU SUN
Format: Patent
Sprache:eng
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Zusammenfassung:Disclosed is an anticancer slow release injection containing clofarabine and cytotoxic drugs, which comprises slow release micro-balloons and dissolvent, wherein the slow release microballoons comprise anti-cancer active constituents and slow release auxiliary materials, the dissolvent being specific dissolvent containing suspension adjuvant. The anticancer active constituents include clofarabine and cytotoxic drugs, the cytotoxic drugs are selected from anti-taxone, alkylating agent, Topo enzyme inhibitor and/or plant alkaloid, The slow release auxiliary materials are selected from polylactic acid and glycollic acid copolymer, polyethylene glycol and polylactic acid copolymer, PLA-COOH copolymer, EVAc, aliphatic acid and sebacylic acid copolymer, The viscosity of the suspension adjuvant is 100-3000cp (at 25-30 deg C),and is selected from sodium carboxymethylcellulose.