Piperazine derivatives as bradyknin antagonist

Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of dise...

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Hauptverfasser: CHEN JIAN J.,ASKEW BEN C.,BISWAS KAUSTAV,CHAU JENNIFER N.,D. AMICO DERIN C.,HARRIED SCOTT,NGUYEN THOMAS,QIAN WENYUAN,ZHU JIAWANG,FOTSCH CHRISTOPHER H.,LI AIWEN,LIU QINGYIAN,NISHIMURA NOBUKU,PETERKIN T, HAN NIANHE,NOMAK RANA,YANG KEVIN
Format: Patent
Sprache:eng
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Zusammenfassung:Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.