5-substituted quinazolinone derivatives

5-substituted quinazolinone derivatives

Compounds which are alpha-1A/B adrenoceptor antagonists and which are represented by Formula I: wherein Q is a monocyclic or bicyclic optionally-substituted heterocyclic ring as defined herein; Z is -C(-O)- or -S(-O)2-; R and R' are lower alkyl; R5 is halogen, cyano, hydroxy, -R6, or -OR6; and...

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1. Verfasser: CHIN ELBERT,COURNOYER RICHARD L.,KEITZ PAUL F.,LEE EUN K.,LOPEZ-TAPIA FRANCISCO J.,MELVILLE CHRIS R.,PADILLA FERNANDO,WEINHARDT KLAUS K
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Compounds which are alpha-1A/B adrenoceptor antagonists and which are represented by Formula I: wherein Q is a monocyclic or bicyclic optionally-substituted heterocyclic ring as defined herein; Z is -C(-O)- or -S(-O)2-; R and R' are lower alkyl; R5 is halogen, cyano, hydroxy, -R6, or -OR6; and R6 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocyclo, or substituted heterocyclo; and pharmaceutically-acceptable salts, hydrates, prodrugs, and isomers thereof.