Hepatitis B surface antigen blending gene and protein for carboxyl terminal containing precursor 32 immune decision cluster

The invention provides a fusion gene encoding a new-type Hepatitis B virus surface antigen and the protein thereof. The nucleotide sequence, encoding Hepatitis B virus preS2 antigen (Met1-Gly26) containing B-cell and T-cell epitopes and polymerized albumin binding site, is fused to 3' terminal...

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Bibliographische Detailangaben
1. Verfasser:	CHANGYAO,JIANG TAN
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides a fusion gene encoding a new-type Hepatitis B virus surface antigen and the protein thereof. The nucleotide sequence, encoding Hepatitis B virus preS2 antigen (Met1-Gly26) containing B-cell and T-cell epitopes and polymerized albumin binding site, is fused to 3' terminal of Hepatitis B virus surface antigenic main protein S gene, then the expression is carried out in yeast expression system. The expressed products, possessing simultaneously antigenicity of S and preS2, are assembled into virus-like particles with diameter of about 20-35nm and are potential for developing novel Hepatitis B vaccines.