Triazole derivatives as inhibitors of 11-beta hydroxysteroid dehydrogenase-1

Triazole derivatives as inhibitors of 11-beta hydroxysteroid dehydrogenase-1

Triazole derivatives of structural formula I are selective inhibitors of the 11 -hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertensi...

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1. Verfasser: WADDELL SHERMAN T.,SANTORELLI GINA M.,MALETIC MILANA M.,LEEMAN AARON H.,GU XIN,GRAHAM DONALD W.,BALKOVEC JAMES M.,ASTER SUSAN D
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Triazole derivatives of structural formula I are selective inhibitors of the 11 -hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.