Crystals including a malic acid salt of a 3-pyrrole substituted 2-indolinone, and compositions thereof

Crystals including a malic acid salt of a 3-pyrrole substituted 2-indolinone, and compositions thereof

The present invention provides a crystal comprising the L-malic acid salt of N-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, wherein the crystal has characteristic diffraction peaks at 13.2 and 24.2 degrees two-theta in a pow...

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Bibliographische Detailangaben
1. Verfasser: HAWLEY MICHAEL,FLECK THOMAS J.,PRESCOTT STEPHEN P.,MALONEY MARK T
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides a crystal comprising the L-malic acid salt of N-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, wherein the crystal has characteristic diffraction peaks at 13.2 and 24.2 degrees two-theta in a powder X-ray diffraction pattern, for use as a medicament.