Recombinant hepatitis A virus antigens obtained in plant cells

Generation of genetic constructions based on modified fragments of the hepatitis A virus (HAV) genome, using the strain M2, isolated in Cuba. Nucleotides sequences of these fragments fused to the appropriated localization and regulation signals, are expressed in transgenic plant. The obtained recomb...

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1. Verfasser: LOPEZ QUESADA ALINA,GONZALEZ BADILLO BEATRIZ,SELMAN-HOUSEIN SOSA GUILLERMO,HERNANDEZ VELASQUEZ ABEL,RIOS BACALLAO JAVIER,ROSABAL AYON YAMILKA,PEREZ MARTINEZ MARLEN,RODRIGUEZ LAY LICEL,GARCIA GONZALEZ
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Sprache:eng
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Zusammenfassung:Generation of genetic constructions based on modified fragments of the hepatitis A virus (HAV) genome, using the strain M2, isolated in Cuba. Nucleotides sequences of these fragments fused to the appropriated localization and regulation signals, are expressed in transgenic plant. The obtained recombinant antigens of the HAV are composed of pentamers and /or empty envelope, able to develop immune response.