Dosage forms comprising a cetp inhibitor and an HMG-CoA reductase inhibitor

A dosage form comprises (1) a solid amorphous dispersion comprising a cholesterol ester transfer protein inhibitor and an acidic concentration-enhancing polymer and (2) an HMG-CoA reductase inhibitor. The solid amorphous dispersion and the HMG-CoA reductase inhibitor are combined in the dosage form...

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1. Verfasser: FRIESEN DWAYNE THOMAS,LORENZ DOUGLAS ALAN,LYON DAVID KEITH,HANCOCK BRUNO CASPAR,MCDERMOTT TIMOTHY JOSEPH,SHANKER RAVI MYSORE
Format: Patent
Sprache:eng
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Zusammenfassung:A dosage form comprises (1) a solid amorphous dispersion comprising a cholesterol ester transfer protein inhibitor and an acidic concentration-enhancing polymer and (2) an HMG-CoA reductase inhibitor. The solid amorphous dispersion and the HMG-CoA reductase inhibitor are combined in the dosage form so that the solid amorphous dispersion and the HMG-CoA reductase inhibitor are substantially separate from one another in the dosage form.