Assay

Assay

The present invention relates to assays useful for predicting whether a compound has the effect to prolong the QT interval as measured by an electrocardiogram in a human. These assays make use of the binding action of dofetilide to the HERG K+ channel, and the propensity of a test compound to influe...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
1. Verfasser: GREENGRASS PAMELA MAY,STEWART MICHAEL,WOOD CLAIREMARGARET
Format: Patent
Sprache:eng
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator GREENGRASS PAMELA MAY,STEWART MICHAEL,WOOD CLAIREMARGARET
description The present invention relates to assays useful for predicting whether a compound has the effect to prolong the QT interval as measured by an electrocardiogram in a human. These assays make use of the binding action of dofetilide to the HERG K+ channel, and the propensity of a test compound to influence that binding action.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN1708689A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN1708689A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN1708689A3</originalsourceid><addsrcrecordid>eNrjZGB1LC5OrORhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfHOfobmBhZmFpaOxoRVAACcIxo3</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Assay</title><source>esp@cenet</source><creator>GREENGRASS PAMELA MAY,STEWART MICHAEL,WOOD CLAIREMARGARET</creator><creatorcontrib>GREENGRASS PAMELA MAY,STEWART MICHAEL,WOOD CLAIREMARGARET</creatorcontrib><description>The present invention relates to assays useful for predicting whether a compound has the effect to prolong the QT interval as measured by an electrocardiogram in a human. These assays make use of the binding action of dofetilide to the HERG K+ channel, and the propensity of a test compound to influence that binding action.</description><edition>7</edition><language>eng</language><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; PHYSICS ; TESTING</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20051214&amp;DB=EPODOC&amp;CC=CN&amp;NR=1708689A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20051214&amp;DB=EPODOC&amp;CC=CN&amp;NR=1708689A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GREENGRASS PAMELA MAY,STEWART MICHAEL,WOOD CLAIREMARGARET</creatorcontrib><title>Assay</title><description>The present invention relates to assays useful for predicting whether a compound has the effect to prolong the QT interval as measured by an electrocardiogram in a human. These assays make use of the binding action of dofetilide to the HERG K+ channel, and the propensity of a test compound to influence that binding action.</description><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>PHYSICS</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZGB1LC5OrORhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfHOfobmBhZmFpaOxoRVAACcIxo3</recordid><startdate>20051214</startdate><enddate>20051214</enddate><creator>GREENGRASS PAMELA MAY,STEWART MICHAEL,WOOD CLAIREMARGARET</creator><scope>EVB</scope></search><sort><creationdate>20051214</creationdate><title>Assay</title><author>GREENGRASS PAMELA MAY,STEWART MICHAEL,WOOD CLAIREMARGARET</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN1708689A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2005</creationdate><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>PHYSICS</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>GREENGRASS PAMELA MAY,STEWART MICHAEL,WOOD CLAIREMARGARET</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GREENGRASS PAMELA MAY,STEWART MICHAEL,WOOD CLAIREMARGARET</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Assay</title><date>2005-12-14</date><risdate>2005</risdate><abstract>The present invention relates to assays useful for predicting whether a compound has the effect to prolong the QT interval as measured by an electrocardiogram in a human. These assays make use of the binding action of dofetilide to the HERG K+ channel, and the propensity of a test compound to influence that binding action.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_epo_espacenet_CN1708689A
source esp@cenet
subjects INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
title Assay
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T07%3A36%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=GREENGRASS%20PAMELA%20MAY,STEWART%20MICHAEL,WOOD%20CLAIREMARGARET&rft.date=2005-12-14&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN1708689A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true