Assay

The present invention relates to assays useful for predicting whether a compound has the effect to prolong the QT interval as measured by an electrocardiogram in a human. These assays make use of the binding action of dofetilide to the HERG K+ channel, and the propensity of a test compound to influe...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser:	GREENGRASS PAMELA MAY,STEWART MICHAEL,WOOD CLAIREMARGARET
Format:	Patent
Sprache:	eng
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to assays useful for predicting whether a compound has the effect to prolong the QT interval as measured by an electrocardiogram in a human. These assays make use of the binding action of dofetilide to the HERG K+ channel, and the propensity of a test compound to influence that binding action.