Improved synthesis of polyanhydrides

The present invention provides a method for forming compounds of Formula HO-C(-O)R1-X-R2-X-R1-C(-O)-O-H wherein compound (I) can be polymerized to provide a polymer that contains therapeutically active compounds. In the compounds of the invention, each R1 is group that will provide the therapeutical...

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Bibliographische Detailangaben
Hauptverfasser:	UHRICH KATHRYN E, WOOD RICHARD D, SCHMELTZER ROBERT C, PUDIL BRYANT J, KANAMATHAREDDY SUSEELA, ANASTASIOU THEODORE J
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	The present invention provides a method for forming compounds of Formula HO-C(-O)R1-X-R2-X-R1-C(-O)-O-H wherein compound (I) can be polymerized to provide a polymer that contains therapeutically active compounds. In the compounds of the invention, each R1 is group that will provide the therapeutically active compound upon hydrolysis of the polymer; each X is independently an ester linkage or an amide linkage; and R2 is a linking group.