Preparation of catifloxacin and purifying method
The present invention provides the preparation and purification of catifloxacin. Cyclized quinolinecarboxylic ester and boric acid are first reacted to form chelate, and the chelate is then reacted with N-methylpiperazine in polar solvent at certain temperature for some time. Through further hydroly...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | The present invention provides the preparation and purification of catifloxacin. Cyclized quinolinecarboxylic ester and boric acid are first reacted to form chelate, and the chelate is then reacted with N-methylpiperazine in polar solvent at certain temperature for some time. Through further hydrolysis with deacidifying agent and separated acid and dilute alkali solution treatment, white catifloxacin powder is produced. The catifloxacin product has good appearance and high purity up to 99.5 %, and the process has high reaction yield simple purification process, and is suitable for industrial production. |
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