Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same

通式(I)的新的取代的烷基氨基哒嗪酮衍生物及其药用可接受的酸加成盐,其中R#-[1]是氢或具有1-4个碳原子的烷基;X是氢或卤素;R#-[2]是氢或具有1-4个碳原子的烷基;n是1、2或3;Q和W各自独立地代表-N=或-CH=;并且R#-[4]和R#-[5]各自独立地代表氢、卤素、三氟甲基或具有1-4个碳原子的烷氧基,它们具有有用的抗焦虑和认知提高性能。 The invention relates to substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R1 is hydrog...

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Hauptverfasser: LEVAY GYOERGY, KOMPAGNE HAJNALKA, MIKLOSNE KOVACS ANIKO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:通式(I)的新的取代的烷基氨基哒嗪酮衍生物及其药用可接受的酸加成盐,其中R#-[1]是氢或具有1-4个碳原子的烷基;X是氢或卤素;R#-[2]是氢或具有1-4个碳原子的烷基;n是1、2或3;Q和W各自独立地代表-N=或-CH=;并且R#-[4]和R#-[5]各自独立地代表氢、卤素、三氟甲基或具有1-4个碳原子的烷氧基,它们具有有用的抗焦虑和认知提高性能。 The invention relates to substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R1 is hydrogen or alkyl having 1-4 carbon atoms; one of X and Y stands for hydrogen or halogen and the other represents a group of the general Formula (II), R2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; R3 stands for hydrogen, alkyl having 1-4 carbon atoms or aryl-(C1-4 alkyl); Z stands for oxygen; or R3 and Z together with the groups placed between them form a piperazine ring; and R4 stands for hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof. The invention compounds are useful in the treatment of anxiolytic conditions and cognitive disorders.