Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells

描述了涉及基因治疗的组合物和方法，特别适用于造血祖(HP)细胞，转导的细胞和获得它们的方法，以及使用它们以在人受试者中提供修饰的造血细胞的移入。本发明特别涉及HP细胞的体外基因治疗来治疗或预防HIV感染。 Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of...

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Bibliographische Detailangaben
Hauptverfasser:	SUN LUN-QUAN, SYMONDS GEOFFERY P, AMADO RAFAEL, MACPHERSON JANET, GERLACH WAYNE, FANNING GREG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	描述了涉及基因治疗的组合物和方法，特别适用于造血祖(HP)细胞，转导的细胞和获得它们的方法，以及使用它们以在人受试者中提供修饰的造血细胞的移入。本发明特别涉及HP细胞的体外基因治疗来治疗或预防HIV感染。 Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of using them to provide prolonged engraftment of modified hematopoietic cells in human subjects. The invention particularly relates to ex vivo gene therapy of HP cells for treatment or prevention of HIV infection.