N-substituted indole derivative preparation method

A process for preparing N-substituted indole derivatives, comprising subjecting N-hydroxymethyl fatty group acidamide with indole or indole derivatives in alcohol or acetic acid with the presence of catalyst, and separating the reaction product, characterized in that the catalyst is type H strong acidic positive ion exchange resin, and the indole derivative is 3-dimethylamino methylindole, 5,6-dichloroindole, 5,6-dibromoindole, 3-dimethylaminomethyl-5,6-dichloroindole, 3-dimethylaminomethyl-5, 6-dibromoindole, 3-dimethylaminomethyl-5, 6-difluorindole, 3-dimethylaminomethyl-2,5,6-trichloroindole, 3-dimethylaminomethyl-2, 5, 6-tribromoindole or 4-bromoindole. the type H strong acidic positive ion exchange resin is sulphonated coal, sulfonated phenylethene and divinylbenzens copolymer or sulfonated phenol formaldehyde resin. Nitrogen is introduced into the reaction. 一种N-取代吲哚衍生物的制备方法，包括在乙醇或乙酸中在催化剂的作用下，使N-羟甲基脂肪基酰胺与吲哚或吲哚衍生物反应，并分离出反应产物，其特征在于所述的催化剂为H型强酸性阳离子交换树脂。所述的吲哚衍生物为3-二甲氨基甲基吲哚、5，6-二氯吲哚、5，6-二溴吲哚、3-二甲氨基甲基-5，6-二氯吲哚、3-二甲氨基甲基-5，6-二溴吲哚、3-二甲氨基甲基-5，6-二氟吲哚、3-二甲氨基甲基-2，5，6-三氯吲哚、3-二甲氨基甲基-2，5，6-三溴吲哚或4-溴吲哚。所述的H型强酸性阳离子交换树脂为磺化煤、磺化苯乙烯-二乙烯苯共聚物或磺化酚醛树脂。所述的反应中通入氮气。本发明的优点是避免了强酸的腐蚀，安全，便于操作，产率高，不产生废酸，将未反应的原料滤出即可以重复使用。