Composition having TNF production inhibitory effect and TNF production inhibitors

本发明的目标是提供一种具有TNF生成抑制效应的组合物以及TNF生成抑制剂，其不会引起副作用或安全问题、可以抑制TNF的任何过量生成并且可用于预防或改善各种TNF介导的疾病，诸如慢性炎症、急性炎症、感染性炎症、自身免疫疾病和过敏性疾病。已经发现肉桂、丁香、甘草根以及生姜的提取物中的每一种都有TNF生成抑制效应。因此，上述目标可以通过具有TNF生成抑制效应的组合物和TNF生成抑制剂来达到，该组合物和抑制剂中至少包含肉桂、丁香、甘草根和生姜提取物中的一种。 The object of the present invention is to provide a composition having a TNF production inhibitory effect and TNF production inhibitors, which raise no adverse effect or safety problem, can inhibit any excessive production of TNF and is useful in the prevention or amelioration of various TNF-mediated diseases, such as chronic inflammatory diseases, acute inflammatory diseases, infectious inflammatory diseases, autoimmune diseases, and allergic diseases. It is found out that cinnamon extracts, clove extracts, licorice root extracts, and ginger extracts each has a TNF production inhibitory effect. Thus, the above object can be achieved by compositions having a TNF production inhibitory effect and TNF production inhibitors which contain at least one of cinnamon extracts, clove extracts, licorice root extracts, and ginger extracts.