Humanized antibodies derived from DD-3B6-22, specific for D-dimer fragment of fibrin

本发明涉及人源化形式的小鼠单克隆抗体DD-3B6/22。该抗体对D-二聚体、交联血纤维蛋白多聚体的降解片段具有特异性。本发明还包括这些抗体在体内检测血块的应用。 The present invention relates generally to carrier molecules derived from one animal or avian species or strains and which are substantially non-immunogenic when exposed to an immune system from a species or strain of a...

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Bibliographische Detailangaben
Hauptverfasser:	F.J. CARR, A.A. HAMILTON
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	本发明涉及人源化形式的小鼠单克隆抗体DD-3B6/22。该抗体对D-二聚体、交联血纤维蛋白多聚体的降解片段具有特异性。本发明还包括这些抗体在体内检测血块的应用。 The present invention relates generally to carrier molecules derived from one animal or avian species or strains and which are substantially non-immunogenic when exposed to an immune system from a species or strain of another animal or avian creature. More particularly, the present invention provides deimmunized immunointeractive molecules and even more particular deimmunized antibodies for use in diagnostic and therapeutic applications.