Anti-inflammatory 17. beta-carbothioate ester derivatives of androstane with a cyclic ester group in position 17. alpha

本发明提供了式(I)的化合物和其溶剂化物、其制备方法以及其在治疗中的应用，式中：R#-[1]表示未被取代或被一个或多个选自氧、甲基、亚甲基和卤素的基团所取代的C#-[1-6]烷基或C#-[1-6]卤代烷基；R#-[2]表示C#-[3-8]环烷基或C#-[3-8]环链烯基；R#-[3]表示氢、甲基(其可以是α或β构型)或亚甲基；R#-[4]和R#-[5]可以相同或不同并且各自表示氢或卤素；和(AA)表示单键或双键。 There are provided compound of formula (I) wherein R 1 represents C 1-6 alkyl or C 1-6 haloalkyl; R 2 represents C 3-8 cycloalkyl or C 3-8 cycloalkenyl either of which may optionally be substituted by one or more groups selected from oxo, methyl, methylene and halogen; R 3 represents hydrogen, methyl (which may be in either the ± or ² configuration) or methylene; R 4 and R 5 are the same or different and each represents hydrogen or halogen; and --- represents a single or a double bond; and solvates thereof, processes for preparing them and their use in therapy.