Method of manufacturing t-20 and t-1249 peptides at commercial scale, and t-20 and t-1249 compositions related thereto

本发明涉及制备商业数量T-20或T-1249组合物，或T-20或T-1249组合物片段的改进方法。该改进包括使用非必要地负载氨基酸或氨基酸衍生物的低空隙空间树脂和/或表面官能化树脂，以产生一个或多个T-20或T-1249片段。 The present invention relates to an improved process for making commercial quantities of a T-20 or a T-1249 composition, or a fragment of a T-20 or a T-1249 composition. The improvement includes using a low void space resin and/or a surface functionalized resin optionally loaded with an amino acid or amino acid derivative to create one or more T-20 or T-1249 fragments.