Prepn process of Adefovir dipivalate

The present invention discloses one improved preparation process of Adefovir dipivalate. In the synthesis of the mother compound 9-[2-(phosphinocarboxyl methoxy) ethyl adenine, trimethyl chlorsilane, rather than expensive trimethyl bromosilane, as material and potassium iodide as nucleophilic reagentare used to reduce cost while the product yield and quality is maintained. The production process of the present invention may be used in industrial production. 本发明公开了一种制备阿德福韦双特戊酯的改进方法。本发明在其母化合物9-[2-(膦羧基甲氧基)乙基腺嘌呤的合成中采用三甲基氯硅烷代替原工艺中的三甲基溴硅烷作原料，并用碘化钾作亲核试剂，从而解决了试剂价格贵且需进口的弊端，并保持原有工艺的产品质量和收率。本发明提供的制备方法生产成本低，可用于工业大生产。