Triazole compounds useful in treating diseases associated with unwanted cytokine activity
本发明涉及下式的4-芳基三唑：式（Ⅰ）其中每个R1独立地选自低级烷基、低级链烯基、低级炔基、低级杂烷基、低级杂烯基、低级杂炔基、杂环烷基、杂芳基、卤素、CN、OR4、SR4、S(O)R4、S(O)2R4和NR4R5；并且Q具有下式（Ⅱ）：所述化合物能用于治疗与过度的细胞因子活性，尤其是与例如来自细胞的白介素-1(IL-1)和肿瘤坏死因子(TNF)有关的疾病。 The present invention relates to 4-aryl triazoles having the formula: wherein R1 is independently selected from the gro...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | VAN RENS JOHN CHARLES NATCHUS MICHAEL GEORGE BLASS BENJAMIN ERIC TULLIS JOSHUA SPECTOR DE BISWANATH CLARK MICHAEL PHILIP |
| description | 本发明涉及下式的4-芳基三唑：式（Ⅰ）其中每个R1独立地选自低级烷基、低级链烯基、低级炔基、低级杂烷基、低级杂烯基、低级杂炔基、杂环烷基、杂芳基、卤素、CN、OR4、SR4、S(O)R4、S(O)2R4和NR4R5；并且Q具有下式（Ⅱ）：所述化合物能用于治疗与过度的细胞因子活性，尤其是与例如来自细胞的白介素-1(IL-1)和肿瘤坏死因子(TNF)有关的疾病。
The present invention relates to 4-aryl triazoles having the formula: wherein R1 is independently selected from the group consisting of: lower alkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower heteroalkenyl, lower heteroalkynyl, heterocycloalkyl, heteroaryl, halo, CN, OR4, SR4, S(O)R4, S(O)2R4, and NR4R5; and Q is has the general formula: said compounds are useful in treating diseases associated with unwanted cytokine activity, inter alia, interleukin-1 (IL-1) and tumor necrosis factor (TNF) from cells. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN1505625A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN1505625A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN1505625A3</originalsourceid><addsrcrecordid>eNqFyj0KwkAQQOE0FqKewbmA4A9rL0GxskpjFYbdiQ6us0tm1hBPL4K91eODN62uTc_4TpHAp2dORYJCUepKBBawntBYbhBYCZUUUDV5RqMAA9sdigwoX_nR0oOFAL3xi22cV5MOo9Li11m1PB2b-ryinFrSjJ6ErK0vG7d2-6077P4fH46jOv0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Triazole compounds useful in treating diseases associated with unwanted cytokine activity</title><source>esp@cenet</source><creator>VAN RENS JOHN CHARLES ; NATCHUS MICHAEL GEORGE ; BLASS BENJAMIN ERIC ; TULLIS JOSHUA SPECTOR ; DE BISWANATH ; CLARK MICHAEL PHILIP</creator><creatorcontrib>VAN RENS JOHN CHARLES ; NATCHUS MICHAEL GEORGE ; BLASS BENJAMIN ERIC ; TULLIS JOSHUA SPECTOR ; DE BISWANATH ; CLARK MICHAEL PHILIP</creatorcontrib><description>本发明涉及下式的4-芳基三唑：式（Ⅰ）其中每个R1独立地选自低级烷基、低级链烯基、低级炔基、低级杂烷基、低级杂烯基、低级杂炔基、杂环烷基、杂芳基、卤素、CN、OR4、SR4、S(O)R4、S(O)2R4和NR4R5；并且Q具有下式（Ⅱ）：所述化合物能用于治疗与过度的细胞因子活性，尤其是与例如来自细胞的白介素-1(IL-1)和肿瘤坏死因子(TNF)有关的疾病。
The present invention relates to 4-aryl triazoles having the formula: wherein R1 is independently selected from the group consisting of: lower alkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower heteroalkenyl, lower heteroalkynyl, heterocycloalkyl, heteroaryl, halo, CN, OR4, SR4, S(O)R4, S(O)2R4, and NR4R5; and Q is has the general formula: said compounds are useful in treating diseases associated with unwanted cytokine activity, inter alia, interleukin-1 (IL-1) and tumor necrosis factor (TNF) from cells.</description><edition>7</edition><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040616&DB=EPODOC&CC=CN&NR=1505625A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040616&DB=EPODOC&CC=CN&NR=1505625A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VAN RENS JOHN CHARLES</creatorcontrib><creatorcontrib>NATCHUS MICHAEL GEORGE</creatorcontrib><creatorcontrib>BLASS BENJAMIN ERIC</creatorcontrib><creatorcontrib>TULLIS JOSHUA SPECTOR</creatorcontrib><creatorcontrib>DE BISWANATH</creatorcontrib><creatorcontrib>CLARK MICHAEL PHILIP</creatorcontrib><title>Triazole compounds useful in treating diseases associated with unwanted cytokine activity</title><description>本发明涉及下式的4-芳基三唑：式（Ⅰ）其中每个R1独立地选自低级烷基、低级链烯基、低级炔基、低级杂烷基、低级杂烯基、低级杂炔基、杂环烷基、杂芳基、卤素、CN、OR4、SR4、S(O)R4、S(O)2R4和NR4R5；并且Q具有下式（Ⅱ）：所述化合物能用于治疗与过度的细胞因子活性，尤其是与例如来自细胞的白介素-1(IL-1)和肿瘤坏死因子(TNF)有关的疾病。
The present invention relates to 4-aryl triazoles having the formula: wherein R1 is independently selected from the group consisting of: lower alkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower heteroalkenyl, lower heteroalkynyl, heterocycloalkyl, heteroaryl, halo, CN, OR4, SR4, S(O)R4, S(O)2R4, and NR4R5; and Q is has the general formula: said compounds are useful in treating diseases associated with unwanted cytokine activity, inter alia, interleukin-1 (IL-1) and tumor necrosis factor (TNF) from cells.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFyj0KwkAQQOE0FqKewbmA4A9rL0GxskpjFYbdiQ6us0tm1hBPL4K91eODN62uTc_4TpHAp2dORYJCUepKBBawntBYbhBYCZUUUDV5RqMAA9sdigwoX_nR0oOFAL3xi22cV5MOo9Li11m1PB2b-ryinFrSjJ6ErK0vG7d2-6077P4fH46jOv0</recordid><startdate>20040616</startdate><enddate>20040616</enddate><creator>VAN RENS JOHN CHARLES</creator><creator>NATCHUS MICHAEL GEORGE</creator><creator>BLASS BENJAMIN ERIC</creator><creator>TULLIS JOSHUA SPECTOR</creator><creator>DE BISWANATH</creator><creator>CLARK MICHAEL PHILIP</creator><scope>EVB</scope></search><sort><creationdate>20040616</creationdate><title>Triazole compounds useful in treating diseases associated with unwanted cytokine activity</title><author>VAN RENS JOHN CHARLES ; NATCHUS MICHAEL GEORGE ; BLASS BENJAMIN ERIC ; TULLIS JOSHUA SPECTOR ; DE BISWANATH ; CLARK MICHAEL PHILIP</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN1505625A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2004</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>VAN RENS JOHN CHARLES</creatorcontrib><creatorcontrib>NATCHUS MICHAEL GEORGE</creatorcontrib><creatorcontrib>BLASS BENJAMIN ERIC</creatorcontrib><creatorcontrib>TULLIS JOSHUA SPECTOR</creatorcontrib><creatorcontrib>DE BISWANATH</creatorcontrib><creatorcontrib>CLARK MICHAEL PHILIP</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VAN RENS JOHN CHARLES</au><au>NATCHUS MICHAEL GEORGE</au><au>BLASS BENJAMIN ERIC</au><au>TULLIS JOSHUA SPECTOR</au><au>DE BISWANATH</au><au>CLARK MICHAEL PHILIP</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Triazole compounds useful in treating diseases associated with unwanted cytokine activity</title><date>2004-06-16</date><risdate>2004</risdate><abstract>本发明涉及下式的4-芳基三唑：式（Ⅰ）其中每个R1独立地选自低级烷基、低级链烯基、低级炔基、低级杂烷基、低级杂烯基、低级杂炔基、杂环烷基、杂芳基、卤素、CN、OR4、SR4、S(O)R4、S(O)2R4和NR4R5；并且Q具有下式（Ⅱ）：所述化合物能用于治疗与过度的细胞因子活性，尤其是与例如来自细胞的白介素-1(IL-1)和肿瘤坏死因子(TNF)有关的疾病。
The present invention relates to 4-aryl triazoles having the formula: wherein R1 is independently selected from the group consisting of: lower alkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower heteroalkenyl, lower heteroalkynyl, heterocycloalkyl, heteroaryl, halo, CN, OR4, SR4, S(O)R4, S(O)2R4, and NR4R5; and Q is has the general formula: said compounds are useful in treating diseases associated with unwanted cytokine activity, inter alia, interleukin-1 (IL-1) and tumor necrosis factor (TNF) from cells.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN1505625A |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Triazole compounds useful in treating diseases associated with unwanted cytokine activity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T06%3A22%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=VAN%20RENS%20JOHN%20CHARLES&rft.date=2004-06-16&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN1505625A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |