Triazole compounds useful in treating diseases associated with unwanted cytokine activity

本发明涉及下式的4-芳基三唑：式（Ⅰ）其中每个R1独立地选自低级烷基、低级链烯基、低级炔基、低级杂烷基、低级杂烯基、低级杂炔基、杂环烷基、杂芳基、卤素、CN、OR4、SR4、S(O)R4、S(O)2R4和NR4R5；并且Q具有下式（Ⅱ）：所述化合物能用于治疗与过度的细胞因子活性，尤其是与例如来自细胞的白介素-1(IL-1)和肿瘤坏死因子(TNF)有关的疾病。 The present invention relates to 4-aryl triazoles having the formula: wherein R1 is independently selected from the gro...

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Bibliographische Detailangaben
Hauptverfasser:	VAN RENS JOHN CHARLES, NATCHUS MICHAEL GEORGE, BLASS BENJAMIN ERIC, TULLIS JOSHUA SPECTOR, DE BISWANATH, CLARK MICHAEL PHILIP
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	本发明涉及下式的4-芳基三唑：式（Ⅰ）其中每个R1独立地选自低级烷基、低级链烯基、低级炔基、低级杂烷基、低级杂烯基、低级杂炔基、杂环烷基、杂芳基、卤素、CN、OR4、SR4、S(O)R4、S(O)2R4和NR4R5；并且Q具有下式（Ⅱ）：所述化合物能用于治疗与过度的细胞因子活性，尤其是与例如来自细胞的白介素-1(IL-1)和肿瘤坏死因子(TNF)有关的疾病。 The present invention relates to 4-aryl triazoles having the formula: wherein R1 is independently selected from the group consisting of: lower alkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower heteroalkenyl, lower heteroalkynyl, heterocycloalkyl, heteroaryl, halo, CN, OR4, SR4, S(O)R4, S(O)2R4, and NR4R5; and Q is has the general formula: said compounds are useful in treating diseases associated with unwanted cytokine activity, inter alia, interleukin-1 (IL-1) and tumor necrosis factor (TNF) from cells.