Tricyclic diazepines as tocolytic oxytocin receptor antagonists

本发明提供了新颖的三环二氮杂�化合物以及用这些化合物治疗和/或预防和/或抑制疾病的方法和药物组合物，所述疾病可以由催产素拮抗剂活性补救或减轻，包括早产、痛经、子宫内膜炎，和用于在剖腹分娩之前抑制分娩。这些化合物也用于增强受精率，增强存活率和使农畜的动情期同步，和可用于中枢神经系统中催产素系统功能异常的预防和治疗，该功能异常包括强制性障碍(OCD)和神经精神病学障碍。 This invention provides novel tricyclic diazepine compounds as well as methods and pharmaceutical compositions utilizing these compounds for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including treatment of preterm labor, dysmenorrhea, endometritis, and for suppressing labor prior to caesarean delivery. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.