New spirotricyclic derivatives and their use as phosphodiesterase-7-inhibitors

本发明提供了属于PDE7抑制剂的具有下列通式(I)、(II)和(III)的化合物及其制备方法及其在治疗与采用PDE7抑制剂的疗法相关的疾病中的应用，其中X#-[1]、X#-[2]、X#-[3]、X#-[4]、X、Y、Z、A和Z#+[1]如本说明书中所定义。 The invention provides compounds which are PDE7 inhibitors, having the following formula (I), (II) and (III), in which X 1 , X 2 , X 3 , X 4 , X, Y, Z, A and Z 1 are as de...

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Bibliographische Detailangaben
Hauptverfasser:	P. BERNARDELLI, P. DUCROT, E. LORTHIOIS
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	本发明提供了属于PDE7抑制剂的具有下列通式(I)、(II)和(III)的化合物及其制备方法及其在治疗与采用PDE7抑制剂的疗法相关的疾病中的应用，其中X#-[1]、X#-[2]、X#-[3]、X#-[4]、X、Y、Z、A和Z#+[1]如本说明书中所定义。 The invention provides compounds which are PDE7 inhibitors, having the following formula (I), (II) and (III), in which X 1 , X 2 , X 3 , X 4 , X, Y, Z, A and Z 1 are as defined in the description, methods for preparing them and their use for the treatment of disorders for which therapy by a PDE7 inhibitor is relevant.