Pharmaceutical composition having reduced tendency for drug crystallization

本发明提供了口服药物组合物，其中含有低水溶性药物、包含至少一种可药用溶剂的溶剂液体和降低浊度的聚合物，其中(a)有相当比例的例如至少约15％重量的药物在溶剂液体中呈溶解形式，和(b)聚合物以足以实质性地抑制药物在模拟的胃液中结晶和/或沉淀的量存在。 Pharmaceutical compositions suitable for oral administration comprising paclitaxel, a solvent, a surfactant, a substituted cellulosic polymer, and optionally but preferably a P-glycoprotein inhibitor. The composition may further comprise a diglyceride or mixture of diglyceride and monoglyceride. The composition generates a supersaturated paclitaxel microemulsion upon contact with water resulting in improved oral bioavailability of paclitaxel.