Hemin chewing tablet and its preparation method

A chaw tablet containing ferricprotoporphyrin chloride and its preparation method. the tablet contains: ferricprotoporphyrin chloride10í½30gú¼mannitol 150í½300gú¼ cane sugar75í½200gú¼microcrystal celluose 25í½ 100gú¼ hydroxypropyl methylcellulose 2.5í½10g and stearic acid10í½20g. The preparation method comprises: putting ferricprotoporphyrin chloride and mannitol into a mixer for mixing for 0.5í½1.5 hours, crushing and sifting by a sieve with 100 meshes, obtaining a diluted mixture; crushing cane sugar and microcrystal celluose, sifting by a sieve with 100 meshes, blending with the diluted mixture; adding 3% hydroxypropyl methylcellulose solution, making particles by a 16-mesh sieve, drying at 55í½60degree C for 3.5í½4.5hours, adding the solution of 10úÑ stearic acid and mixing, drying at 55í½60degree C for 1.5í½2.5 hours, making particles by a 14-mesh sieve and tabletting. The finished product is chocolatebrown, the absorbing rate is 15í½20úÑ, which is mainly used to treat iron deficiency anemia. 本发明是一种氯高铁血红素咀嚼片及其制备方法，其组成为：氯高铁血红素10～30g，甘露醇150～300g，蔗糖75～200g，微晶纤维素25～100g，羟丙基甲基纤维素2.5～10g，硬脂酸10～20g，氯高铁血红素与甘露醇按等量递加法放置在混合机中混合0.5～1.5小时，然后一起粉碎过100目筛制成稀释散，蔗糖和微晶纤维素一起粉碎过100目筛后，再与稀释散混合均匀，加入浓度为3％的羟丙基甲基纤维素溶液制软材，16目制粒，在55～60℃干燥3.5～4.5小时，加入浓度为10％的硬脂酸溶液混合均匀，在55～60℃干燥1.5～2.5小时，14目整粒后压片，成品为棕褐色异型片，吸收率15～20％，主治缺铁性贫血，稳定性好、剂量易于控制、携带及服用方便。