Reversible gelling system for ocular drug delivery
本发明提供了用于局部给药的眼用含水组合物，其包含：(a)环氧丙烷和环氧乙烷的嵌段共聚物，其浓度足以在环境温度下提供低于约25厘泊的粘度，并且当局部施用于患者时提供约25至约55厘泊的粘度；(b)羟丙基甲基纤维素，其浓度足以改善由该嵌段共聚物形成的凝胶的耐久性。本发明进一步提供眼用药物的给药方法。 The invention provides an ophthalmic aqueous composition for topical administration, comprising:(a) a block copolymer of propylene oxide and ethylene o...
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| Format: | Patent |
| Sprache: | chi ; eng |
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| Zusammenfassung: | 本发明提供了用于局部给药的眼用含水组合物，其包含：(a)环氧丙烷和环氧乙烷的嵌段共聚物，其浓度足以在环境温度下提供低于约25厘泊的粘度，并且当局部施用于患者时提供约25至约55厘泊的粘度；(b)羟丙基甲基纤维素，其浓度足以改善由该嵌段共聚物形成的凝胶的耐久性。本发明进一步提供眼用药物的给药方法。
The invention provides an ophthalmic aqueous composition for topical administration, comprising:(a) a block copolymer of propylene oxide and ethylene oxide in concentration sufficient to provide viscosity of less than about 25 centipoise at ambient temperature and viscosity of from about 25 to about 55 centipoise when applied topically to a patient;(b) hydroxypropyl methylcellulose in concentration sufficient to improve the durability of the gel formed by the block copolymer.The invention further provides a method for administering ophthalmic pharmaceuticals. |
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