Process for preparation of 2-carboxy-alkyl (aryl) phosphonic acids and anhydrides

Process for preparation of 2-carboxy-alkyl (aryl) phosphonic acids and anhydrides

本发明涉及一种改良的水解方法，所述方法包括一种通过对加入丙烯酸酯化反应混合物中的水的控制和对温度的控制来制备2-羧基基烷基(芳基)次膦酸的方法。还公开了通过对加入水进行控制来制备2-羧基烷基(芳基)次膦酸环酐的方法，其中通过控制使得每摩尔加入到丙烯酸酯化反应的二氯(芳基)膦加入最高可达约1摩尔水，并且对温度进行控制。 An improved hydrolysis process comprising a process for the preparation of 2-carboxyalkyl(aryl)phosphinic acid using a controlled addition o...

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Bibliographische Detailangaben
Hauptverfasser: F.E. PAULIK, D.J. WEINKAUFF
Format: Patent
Sprache:chi ; eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:本发明涉及一种改良的水解方法，所述方法包括一种通过对加入丙烯酸酯化反应混合物中的水的控制和对温度的控制来制备2-羧基基烷基(芳基)次膦酸的方法。还公开了通过对加入水进行控制来制备2-羧基烷基(芳基)次膦酸环酐的方法，其中通过控制使得每摩尔加入到丙烯酸酯化反应的二氯(芳基)膦加入最高可达约1摩尔水，并且对温度进行控制。 An improved hydrolysis process comprising a process for the preparation of 2-carboxyalkyl(aryl)phosphinic acid using a controlled addition of water to an acrylation reaction mixture, and control of the temperature. Preparation of 2-carboxyalkyl(aryl)phosphinic acid cyclic anhydride is disclosed using a controlled addition of water, wherein up to about one mole of water per mole of dichloro(aryl)-phosphine charged to the acrylation reaction is added, and temperature is controlled.