Method for preparing carbonyl alpha-substituted nitrogen compounds

The present invention relates to a process of producing carbonyl ª‡-substituted nitrogen-containing compounds, which comprises reacting a halo-ketone or a-halo-aldehyde with primary amine, secondary amine or heterocycle compound containing nitrogen atome in the presence of Lewis acid and in the presence of absence of solvent. This process has the advantages of simple and easy-to-operate procedure, mild reacting condition, low energy-consumption, high yield, etc. thus improves efficiently the utilization and productivity of the equipment. 本发明涉及一种制备羰基α-取代的含氮化合物的方法，该方法包括：在路易斯酸存在下，在存在溶剂或不存在溶剂的情况下，使α-卤代酮或α-卤代醛与伯胺、仲胺或含有氮原子的杂环化合物反应。该方法具有工艺操作简单易行、反应条件温和、能耗低、反应收率高等优点，从而有效地提高了设备利用率和产能。