Macrolide formulations for inhalation and methods of treatment of endobronchial infections

描述了用于通过气溶胶传递的大环内酯制剂，例如氨基红霉素制剂。浓缩的氨基红霉素制剂含有治疗易感性细菌导致的感染的有效量的氨基红霉素。还描述了具有容器的单剂装置，该容器中含有在生理可接受的载体内的大环内酯抗生素的制剂。还描述了治疗肺部感染的方法，该方法是通过作为质量中位空气动力直径为1-5微米的气溶胶传递的制剂。 Macrolide formulations, such as an erythromycylamine formulation, for delivery by aerosolization are described. The concentrated erythromycylami...

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Bibliographische Detailangaben
Hauptverfasser:	P.B. CHALLONER, W.R. BAKER, R.M. SHAWAR
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	描述了用于通过气溶胶传递的大环内酯制剂，例如氨基红霉素制剂。浓缩的氨基红霉素制剂含有治疗易感性细菌导致的感染的有效量的氨基红霉素。还描述了具有容器的单剂装置，该容器中含有在生理可接受的载体内的大环内酯抗生素的制剂。还描述了治疗肺部感染的方法，该方法是通过作为质量中位空气动力直径为1-5微米的气溶胶传递的制剂。 Macrolide formulations, such as an erythromycylamine formulation, for delivery by aerosolization are described. The concentrated erythromycylamine formulations contain an amount of erythromycylamine effective to treat infections caused by susceptible bacteria. Unit dose devices having a container containing a formulation of the macrolide antibiotic in a physiologically acceptable carrier are also described. Methods for treatment of pulmonary infections by a formulation (liquid solution, suspension, or dry powder) delivered as an aerosol having mass median aerodynamic diameter predominantly between 1 to 5 mu m are also described.